:root{
  --bg:#070A12;
  --panel:#0B1222;
  --panel2:#0E1730;
  --border:rgba(140,160,255,.18);
  --text:#EAF0FF;
  --muted:rgba(234,240,255,.68);
  --accent:#7C5CFF;
  --accent2:#00D4FF;
  --shadow: 0 18px 60px rgba(0,0,0,.45);
  --nav-surface: linear-gradient(135deg, rgba(18, 29, 55, .78), rgba(10, 17, 33, .64));
  --nav-pop-a: #ff4fd8;
  --nav-pop-b: #32f3ff;
  --nav-pop-c: #ffe14d;
  --title-outline-a:#32f3ff;
  --title-outline-b:#7c5cff;
  --title-outline-c:#ff4fd8;
}


*{ box-sizing:border-box; }

html,body{
  margin:0;
  background: radial-gradient(1200px 700px at 20% 10%, rgba(124,92,255,.18), transparent 55%),
              radial-gradient(900px 600px at 80% 30%, rgba(0,212,255,.12), transparent 60%),
              var(--bg);
  color:var(--text);
  font-family: system-ui, -apple-system, Segoe UI, Roboto, Arial;
}

body.home-page{
  min-height: 100vh;
  background:
    radial-gradient(1200px 640px at 18% 6%, rgba(124,92,255,.22), transparent 58%),
    radial-gradient(980px 700px at 82% 20%, rgba(0,212,255,.16), transparent 62%),
    linear-gradient(160deg, #060A14 0%, #090F1D 52%, #0B1324 100%);
}

.bg-grid{
  position: fixed;
  inset: 0;
  z-index: 0;
  pointer-events:none;
  background-image:
    linear-gradient(to right, rgba(140,160,255,.04) 1px, transparent 1px),
    linear-gradient(to bottom, rgba(140,160,255,.04) 1px, transparent 1px);
  background-size: 56px 56px;
  mask-image: radial-gradient(circle at 50% 15%, rgba(0,0,0,.92), rgba(0,0,0,.58) 54%, rgba(0,0,0,0) 92%);
  opacity: .52;
}


.home-fx{
  position: fixed;
  inset: 0;
  pointer-events: none;
  z-index: 0;
  overflow: hidden;
}

.home-fx .ring-a,
.home-fx .ring-b{
  position:absolute;
  border-radius: 999px;
  border: 1px solid rgba(140,160,255,.14);
  box-shadow: inset 0 0 38px rgba(124,92,255,.08), 0 0 80px rgba(0,212,255,.08);
}

.home-fx .ring-a{
  width: 42vmax;
  height: 42vmax;
  left: -12vmax;
  top: -16vmax;
  animation: ringDrift 22s linear infinite;
}

.home-fx .ring-b{
  width: 34vmax;
  height: 34vmax;
  right: -9vmax;
  top: 2vmax;
  animation: ringDriftReverse 18s linear infinite;
}

.home-fx .beam-a,
.home-fx .beam-b{
  position: absolute;
  inset: auto -24% -22% -24%;
  height: 40vh;
  background: linear-gradient(90deg, transparent, rgba(124,92,255,.14), rgba(0,212,255,.16), transparent);
  filter: blur(36px);
  transform-origin: center;
}

.home-fx .beam-a{ animation: beamSweep 14s ease-in-out infinite; }
.home-fx .beam-b{ animation: beamSweep 14s ease-in-out infinite reverse; opacity:.65; }

.home-fx .orb{
  position:absolute;
  border-radius: 50%;
  filter: blur(2px);
  mix-blend-mode: screen;
}

.home-fx .orb-a{
  width: 210px;
  height: 210px;
  left: 18%;
  top: 28%;
  background: radial-gradient(circle at 35% 35%, rgba(255,255,255,.65), rgba(124,92,255,.36) 40%, rgba(124,92,255,0) 72%);
  animation: orbPulse 9s ease-in-out infinite;
}

.home-fx .orb-b{
  width: 180px;
  height: 180px;
  right: 22%;
  top: 34%;
  background: radial-gradient(circle at 35% 35%, rgba(255,255,255,.45), rgba(0,212,255,.4) 40%, rgba(0,212,255,0) 72%);
  animation: orbPulse 11s ease-in-out infinite reverse;
}

.home-fx .orb-c{
  width: 130px;
  height: 130px;
  right: 36%;
  top: 12%;
  background: radial-gradient(circle at 40% 40%, rgba(255,255,255,.52), rgba(255,79,216,.32) 42%, rgba(255,79,216,0) 72%);
  animation: orbFloat 8s ease-in-out infinite;
}

/* --- MISE EN PAGE PLEIN ECRAN --- */
.container {
    position: relative;
    z-index: 1;
    width: 99%;      /* Occupe presque tout l'écran */
    max-width: none; /* Supprime la limite de largeur */
    margin: 0 auto;
    padding: 10px;
}

.brand{
  display:flex;
  align-items:center;
  gap:12px;
  font-weight:700;
  letter-spacing:.02em;
}

.brand-title{
  position: relative;
  font-size: clamp(1.25rem, 1.55vw, 1.92rem);
  line-height: 1.05;
  font-weight: 900;
  letter-spacing: .12em;
  text-transform: uppercase;
  color: #f5f8ff;
  text-shadow:
    0 0 1px rgba(255,255,255,.8),
    0 0 18px rgba(50,243,255,.28),
    0 0 34px rgba(124,92,255,.22);
}

.dot{
  width:10px;
  height:10px;
  border-radius:999px;
  background: linear-gradient(135deg, var(--accent), var(--accent2));
  box-shadow: 0 0 22px rgba(124,92,255,.55);
}

.subtitle{ color: var(--muted); margin-top: 6px; }

.topbar{
  display:flex;
  justify-content:space-between;
  align-items:flex-start;
  gap:12px;
  flex-wrap:wrap;
  margin-bottom: 18px;
}

.nav{ display:flex; gap:10px; flex-wrap:wrap; }

.nav-link{
  position: relative;
  isolation: isolate;
}

.nav-link::after{
  content:"";
  position:absolute;
  left: 10px;
  right: 10px;
  bottom: 3px;
  height: 2px;
  border-radius: 999px;
  background: linear-gradient(90deg, var(--nav-pop-a), var(--nav-pop-b), var(--nav-pop-c));
  transform: scaleX(0);
  transform-origin: left;
  transition: transform .18s ease;
  opacity: .92;
}

.nav-link:hover::after,
.nav-link[aria-current="page"]::after{
  transform: scaleX(1);
}

.nav-link-active{
  border-color: rgba(50, 243, 255, .62);
  box-shadow: 0 0 0 1px rgba(50,243,255,.22), 0 12px 30px rgba(0,0,0,.35);
}

.grid{
  display:grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 14px;
}

@media (max-width: 980px){
  .grid{ grid-template-columns: 1fr; }
}

.card{
  background: linear-gradient(180deg, rgba(14,23,48,.92), rgba(11,18,34,.92));
  border: 1px solid var(--border);
  border-radius: 18px;
  padding: 18px;
  box-shadow: var(--shadow);
  backdrop-filter: blur(10px);
  transform: translateY(0);
  transition: transform .18s ease, border-color .18s ease, box-shadow .18s ease;
  animation: fadeInUp .28s ease both;
}

.card:hover{
  transform: translateY(-2px);
  border-color: rgba(124,92,255,.38);
  box-shadow: 0 26px 70px rgba(0,0,0,.52);
}

.glow{
  position:relative;
  overflow:hidden;
}
.glow:before{
  content:"";
  position:absolute;
  inset:-40%;
  background: radial-gradient(circle at 30% 30%, rgba(124,92,255,.22), transparent 55%),
              radial-gradient(circle at 60% 60%, rgba(0,212,255,.16), transparent 55%);
  transform: rotate(8deg);
  opacity:.9;
  pointer-events:none;
}

h1{ margin: 0 0 10px 0; font-size: 28px; }
h2{ margin: 0 0 8px 0; font-size: 18px; }
p{ margin: 0; color: var(--muted); line-height: 1.5; }

.actions{ margin-top: 14px; display:flex; gap:10px; flex-wrap:wrap; }

/* BOUTONS COMPACTS */
.btn{
  display:inline-flex;
  align-items:center;
  gap:8px;
  padding: 4px 10px; /* Réduit pour le mode compact */
  border-radius: 12px;
  border: 1px solid rgba(124,92,255,.45);
  background: linear-gradient(135deg, rgba(124,92,255,.18), rgba(0,212,255,.08));
  color: var(--text);
  text-decoration:none;
  box-shadow: 0 12px 30px rgba(0,0,0,.35);
  transition: transform .12s ease, filter .12s ease, border-color .12s ease;
  will-change: transform;
  font-size: 11px; /* Police réduite */
}

.btn:hover{
  transform: translateY(-1px);
  border-color: rgba(0,212,255,.55);
  filter: brightness(1.06);
}

.btn:active{
  transform: translateY(0px) scale(.99);
}

.btn-secondary{
  border-color: rgba(0,212,255,.42);
  background: linear-gradient(135deg, rgba(0,212,255,.14), rgba(124,92,255,.08));
}

.btn-ghost{
  border-color: rgba(140,160,255,.20);
  background: rgba(255,255,255,.03);
}

.muted{ color: var(--muted); }

.footer{ margin-top: 18px; }

.pill-row{ display:flex; gap:10px; flex-wrap:wrap; margin-top: 12px; }
.pill{
  border: 1px solid rgba(140,160,255,.18);
  background: rgba(255,255,255,.03);
  border-radius: 999px;
  padding: 2px 6px; /* Compact */
  color: var(--muted);
  font-size: 10px; /* Compact */
}


.home-page .topbar{
  position: relative;
  overflow: hidden;
  background: var(--nav-surface);
  border: 1px solid rgba(140,160,255,.2);
  border-radius: 20px;
  padding: 16px 18px;
  box-shadow: 0 20px 58px rgba(0,0,0,.4);
  backdrop-filter: blur(10px);
}

.home-page .topbar::after{
  content:"";
  position:absolute;
  inset:-120% -30% auto -30%;
  height: 220%;
  background: conic-gradient(from 0deg, rgba(50,243,255,.14), rgba(124,92,255,.12), rgba(255,79,216,.12), rgba(50,243,255,.14));
  animation: rotateHalo 16s linear infinite;
  pointer-events:none;
}

.home-page .brand{
  position: relative;
  z-index: 1;
}

.home-page .brand-title{
  -webkit-text-stroke: .7px rgba(255,255,255,.45);
  border: 1px solid rgba(140,160,255,.2);
  border-radius: 12px;
  padding: 4px 10px 6px;
  background: linear-gradient(120deg, rgba(10,16,36,.86), rgba(20,30,62,.65));
  box-shadow: inset 0 0 0 1px rgba(255,255,255,.05), 0 0 22px rgba(124,92,255,.2);
  animation: titleFlux 7s ease-in-out infinite;
}

.home-page .subtitle{
  position: relative;
  z-index: 1;
  letter-spacing: .02em;
  color: rgba(234,240,255,.8);
}

.home-page .card{
  position: relative;
  overflow: hidden;
  border: 1px solid rgba(140,160,255,.24);
  background:
    linear-gradient(180deg, rgba(14,24,50,.95), rgba(10,16,32,.93));
  box-shadow:
    inset 0 1px 0 rgba(255,255,255,.06),
    0 22px 62px rgba(0,0,0,.42);
}

.home-page .card::after{
  content:"";
  position:absolute;
  inset: -120% -10% auto -10%;
  height: 150%;
  background: linear-gradient(120deg, transparent 22%, rgba(50,243,255,.14), rgba(255,79,216,.08), transparent 62%);
  transform: translateX(-42%) rotate(12deg);
  animation: cardSweep 10s ease-in-out infinite;
  pointer-events:none;
}

.home-page .card h2{
  letter-spacing: .03em;
}

.signature-badge{
  position: fixed;
  right: 14px;
  bottom: 12px;
  z-index: 15;
  display: inline-flex;
  align-items: center;
  gap: 10px;
  padding: 9px 14px;
  font-size: 11px;
  color: rgba(234,240,255,.9);
  background: linear-gradient(125deg, rgba(18,26,52,.88), rgba(11,20,40,.82));
  border: 1px solid rgba(50,243,255,.36);
  border-radius: 14px;
  backdrop-filter: blur(7px);
  box-shadow: 0 10px 26px rgba(0,0,0,.32), 0 0 0 1px rgba(255,79,216,.15);
  animation: badgeFloat 5.5s ease-in-out infinite;
}

.signature-label{
  text-transform: uppercase;
  letter-spacing: .12em;
  color: rgba(234,240,255,.62);
  font-size: 9px;
}

.signature-name{
  font-weight: 800;
  letter-spacing: .04em;
  color: #9cf6ff;
  text-shadow: 0 0 18px rgba(50,243,255,.25);
}

.easter-egg{
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  font-size: 11px;
  color: #ffd46a;
  opacity: .92;
  padding: 2px 6px;
  border-radius: 999px;
  background: rgba(255,212,106,.09);
  border: 1px solid rgba(255,212,106,.32);
  transition: transform .24s ease, opacity .24s ease, box-shadow .24s ease;
}

.signature-badge:hover .easter-egg{
  transform: translateY(-1px) scale(1.06);
  opacity: 1;
  box-shadow: 0 0 18px rgba(255,212,106,.22);
}

@media (max-width: 700px){
  .signature-badge{
    right: 8px;
    bottom: 8px;
    gap: 8px;
    padding: 7px 10px;
  }

  .signature-label{ display:none; }
}

@keyframes fadeInUp{
  from{ opacity:0; transform: translateY(10px); }
  to{ opacity:1; transform: translateY(0); }
}

@keyframes ringDrift{
  0%{ transform: rotate(0deg) scale(1); opacity:.6; }
  50%{ transform: rotate(180deg) scale(1.05); opacity:.82; }
  100%{ transform: rotate(360deg) scale(1); opacity:.6; }
}

@keyframes ringDriftReverse{
  0%{ transform: rotate(360deg) scale(1); opacity:.55; }
  50%{ transform: rotate(180deg) scale(.95); opacity:.78; }
  100%{ transform: rotate(0deg) scale(1); opacity:.55; }
}

@keyframes beamSweep{
  0%,100%{ transform: translateX(-6%) rotate(-2deg); opacity:.3; }
  50%{ transform: translateX(6%) rotate(2deg); opacity:.68; }
}

@keyframes orbPulse{
  0%,100%{ transform: translate3d(0,0,0) scale(1); opacity:.48; }
  50%{ transform: translate3d(8px,-10px,0) scale(1.16); opacity:.8; }
}

@keyframes orbFloat{
  0%,100%{ transform: translateY(0); opacity:.42; }
  50%{ transform: translateY(-12px); opacity:.82; }
}

@keyframes rotateHalo{
  from{ transform: rotate(0deg); }
  to{ transform: rotate(360deg); }
}

@keyframes titleFlux{
  0%,100%{
    border-color: rgba(50,243,255,.35);
    box-shadow: inset 0 0 0 1px rgba(255,255,255,.05), 0 0 22px rgba(124,92,255,.2);
  }
  33%{
    border-color: rgba(124,92,255,.58);
    box-shadow: inset 0 0 0 1px rgba(255,255,255,.05), 0 0 26px rgba(50,243,255,.24);
  }
  66%{
    border-color: rgba(255,79,216,.55);
    box-shadow: inset 0 0 0 1px rgba(255,255,255,.05), 0 0 28px rgba(255,79,216,.22);
  }
}

@keyframes cardSweep{
  0%,100%{ transform: translateX(-46%) rotate(12deg); opacity:0; }
  35%{ opacity:.35; }
  50%{ transform: translateX(28%) rotate(12deg); opacity:.5; }
  65%{ opacity:.35; }
}

@keyframes badgeFloat{
  0%,100%{ transform: translateY(0); }
  50%{ transform: translateY(-3px); }
}

/* --- TABLEAU COMPACT ET RESPONSIVE --- */

.table-wrap {
    width: 100%;
    overflow-x: auto; /* Scroll uniquement si écran trop petit */
    border-radius: 16px;
    border: 1px solid rgba(140,160,255,.18);
}

table {
    width: 100%;
    table-layout: auto; /* Laisse le navigateur gérer les largeurs */
    border-collapse: collapse;
}

th, td {
    padding: 6px 4px;       /* Padding réduit */
    border-bottom: 1px solid rgba(140,160,255,.12);
    vertical-align: middle; /* Alignement vertical centré c'est plus joli */
    font-size: 12px;        /* Police réduite */
    
    /* IMPORTANT : Gestion des retours à la ligne */
    white-space: normal;    /* Autorise le texte sur plusieurs lignes */
    word-wrap: break-word;  /* Coupe les mots si nécessaire */
}

/* Colonnes spécifiques : largeur max pour forcer le retour à la ligne */
td:nth-child(6){ max-width: 200px; }  /* consequence */
td:nth-child(8){ max-width: 220px; }  /* actionnabilité */
td:nth-child(9){ max-width: 220px; }  /* commentaire */

/* Styles pour les inputs dans le tableau */
td input, td select, td textarea {
    background: rgba(255,255,255,.04);
    color: var(--text);
    border: 1px solid rgba(140,160,255,.18);
    width: 100%;
    min-width: unset !important; /* Force la largeur à suivre la cellule */
    max-width: 100%;
    font-size: 12px;
    padding: 4px;
    height: auto;
    outline: none;
    border-radius: 6px;
}

select option{
  background: #0B1222;
  color: var(--text);
}

.mono {
    font-family: 'Consolas', monospace;
    font-size: 11px;
    letter-spacing: -0.5px;
}
.input {
  background: rgba(255,255,255,.04);
  color: var(--text);
  border: 1px solid rgba(140,160,255,.18);
  width: 100%;
  font-size: 12px;
  padding: 8px;
  border-radius: 8px;
}

/* --- AJOUTS POUR LA GESTION VARIANTS --- */

/* Code couleur des lignes du tableau selon statut */
tr.row-validated td { background: rgba(58, 197, 114, 0.08) !important; border-bottom: 1px solid rgba(58, 197, 114, 0.3); }
tr.row-validated td:first-child { border-left: 4px solid #3ac572; }

tr.row-invalidated td { background: rgba(255, 95, 109, 0.08) !important; border-bottom: 1px solid rgba(255, 95, 109, 0.3); }
tr.row-invalidated td:first-child { border-left: 4px solid #ff5f6d; }

tr.row-tovalidate td { background: rgba(255, 190, 80, 0.05) !important; }
tr.row-tovalidate td:first-child { border-left: 4px solid #ffbe50; }

tr.row-triage td:first-child { border-left: 4px solid rgba(140,160,255,0.3); }

/* Badges Tier AMP */
.tier-badge {
    font-weight: bold;
    padding: 2px 8px;
    border-radius: 6px;
    font-size: 11px;
    display: inline-block;
}
.tier-ia{ background: rgba(229,57,53,.2); color:#ffb4b1; border:1px solid rgba(229,57,53,.45); }
.tier-ib{ background: rgba(239,83,80,.2); color:#ffc4c2; border:1px solid rgba(239,83,80,.45); }
.tier-iic{ background: rgba(142,68,173,.22); color:#e9c9ff; border:1px solid rgba(142,68,173,.45); }
.tier-iid{ background: rgba(165,105,189,.24); color:#efd7ff; border:1px solid rgba(165,105,189,.45); }
.tier-iii{ background: rgba(31,120,180,.2); color:#bde9ff; border:1px solid rgba(31,120,180,.45); }
.tier-unknown{ background: rgba(140,160,255,.1); color:#a9b7ff; border:1px solid rgba(140,160,255,.35); }

/* Badges Classe AMP (alignées avec NGS + synoptique PDF) */
.class-badge {
  font-weight: 700;
  padding: 2px 8px;
  border-radius: 999px;
  font-size: 11px;
  display: inline-flex;
  align-items: center;
  border: 1px solid transparent;
}
.class-i{ background: rgba(229,57,53,.2); color:#ffb4b1; border-color: rgba(229,57,53,.45); }
.class-ii{ background: rgba(142,68,173,.22); color:#e9c9ff; border-color: rgba(142,68,173,.45); }
.class-iii{ background: rgba(31,120,180,.2); color:#bde9ff; border-color: rgba(31,120,180,.45); }
.class-unknown{ background: rgba(140,160,255,.1); color:#a9b7ff; border-color: rgba(140,160,255,.35); }

/* Badges ACMG */
.acmg-badge {
  font-weight: bold;
  padding: 2px 8px;
  border-radius: 6px;
  font-size: 11px;
  display: inline-block;
  border: 1px solid transparent;
  line-height: 1.2;
  white-space: nowrap;
}
.acmg-chip{
  display:inline-block !important;
  padding: 2px 8px;
  border-radius: 6px;
  border: 1px solid transparent;
  font-weight: bold;
  font-size: 11px;
  line-height: 1.2;
  white-space: nowrap;
}
.acmg-5, .acmg-chip.acmg-5{ background: #FDE8E7; color:#8F2E2A; border-color: #F2B7B3; }
.acmg-4, .acmg-chip.acmg-4{ background: #F2E9F8; color:#5D3D75; border-color: #D5BDE8; }
.acmg-3, .acmg-chip.acmg-3{ background: #EAF4FE; color:#1F4D77; border-color: #BDD9F7; }
.acmg-2, .acmg-chip.acmg-2{ background: #E7F9F4; color:#1F6454; border-color: #BCEADF; }
.acmg-1, .acmg-chip.acmg-1{ background: #E7F7EE; color:#1D603A; border-color: #BCE6CE; }
.acmg-unknown, .acmg-chip.acmg-unknown{ background: rgba(140,160,255,.1); color:#a9b7ff; border-color: rgba(140,160,255,.35); }

.acmg-badge.acmg-5,
.acmg-badge.acmg-4,
.acmg-badge.acmg-3,
.acmg-badge.acmg-2,
.acmg-badge.acmg-1 {
  text-shadow: 0 0 12px rgba(255,255,255,.12);
}

/* Cellules composées (Grouping) */
.cell-group { display: flex; flex-direction: column; gap: 4px; }
.cell-main { font-weight: bold; font-size: 13px; color: var(--text); }
.cell-sub { font-size: 11px; color: var(--muted); font-family: 'Consolas', monospace; }

.metric-grid {
    display: grid;
    grid-template-columns: auto 1fr;
    gap: 4px 8px;
    font-size: 11px;
}
.metric-label { color: var(--muted); text-transform: uppercase; font-size: 9px; }
.metric-value { font-family: 'Consolas', monospace; text-align: right; }

/* Filtres rapides (Javascript) */
.filter-bar {
    display: flex;
    gap: 10px;
    margin-bottom: 12px;
    background: rgba(255,255,255,0.03);
    padding: 8px;
    border-radius: 12px;
    border: 1px solid var(--border);
}
.filter-btn {
    cursor: pointer;
    opacity: 0.6;
    transition: all 0.2s;
}
.filter-btn.active { opacity: 1; font-weight: bold; text-decoration: underline; color: var(--accent2); }

/* Ajustement inputs dans tableau */
.dense-input { padding: 6px !important; font-size: 12px !important; background: rgba(0,0,0,0.2) !important; }


/* --- NOUVEAUTÉS DESIGN (V2) --- */

/* 1. Nouveau Header de Cas (Hero Section) */
.case-hero {
    background: linear-gradient(90deg, rgba(11,18,34,0.95) 0%, rgba(14,23,48,0.8) 100%);
    border: 1px solid var(--accent);
    border-radius: 16px;
    padding: 20px;
    margin-bottom: 24px;
    display: flex;
    align-items: center;
    justify-content: space-between;
    box-shadow: 0 10px 30px rgba(0,0,0,0.4);
    position: relative;
    overflow: hidden;
}
.case-hero::before {
    content: ""; position: absolute; top: 0; left: 0; width: 6px; height: 100%;
    background: var(--accent);
}
.hero-title { font-size: 24px; font-weight: 800; color: #fff; letter-spacing: -0.5px; }
.hero-meta { display: flex; gap: 20px; margin-top: 8px; font-size: 14px; color: var(--muted); }
.hero-badge { 
    background: rgba(124,92,255,0.2); border: 1px solid rgba(124,92,255,0.4); 
    color: #bfaaff; padding: 4px 12px; border-radius: 99px; font-weight: 600; text-transform: uppercase; font-size: 11px;
}

/* 2. Colonne Identité (Gene Pill & Altération) */
.gene-pill {
    display: inline-block;
    background: linear-gradient(135deg, var(--accent), #5e42d6);
    color: white;
    font-weight: 800;
    font-size: 15px;
    padding: 6px 14px;
    border-radius: 99px;
    box-shadow: 0 4px 12px rgba(124,92,255,0.4);
    margin-bottom: 6px;
}
.alteration-badge {
    display: inline-block;
    font-size: 11px;
    font-weight: 600;
    padding: 3px 8px;
    border-radius: 6px;
    border: 1px solid rgba(255,255,255,0.1);
    background: rgba(255,255,255,0.05);
}
/* Couleurs dynamiques simulées (sera appliqué via JS ou logique backend idéalement, ici CSS générique) */
.alt-missense { color: #ffbe50; border-color: rgba(255,190,80,0.3); background: rgba(255,190,80,0.1); }
.alt-frameshift, .alt-stop { color: #ff5f6d; border-color: rgba(255,95,109,0.3); background: rgba(255,95,109,0.1); }
.alt-other { color: #00d4ff; border-color: rgba(0,212,255,0.3); background: rgba(0,212,255,0.1); }

/* 3. Colonne Métriques (Boîtes séparées) */
.metrics-container { display: flex; flex-direction: column; gap: 6px; }
.metric-box {
    display: flex; justify-content: space-between; align-items: center;
    background: rgba(0,0,0,0.3);
    border: 1px solid rgba(140,160,255,0.1);
    border-radius: 6px;
    padding: 4px 8px;
}
.m-label { font-size: 9px; text-transform: uppercase; color: var(--muted); font-weight: 600; }
.m-value { font-family: 'Consolas', monospace; font-weight: bold; font-size: 12px; }
.val-high { color: #f8ef00; } /* rétrocompat: ancien style VAF > cellules tumorales */

/* 4. Visualisation Workflow (Stepper) */
.stepper { display: flex; align-items: center; gap: 2px; margin-bottom: 8px; opacity: 0.8; }
.step { height: 4px; flex: 1; background: rgba(255,255,255,0.1); border-radius: 2px; }
.step.active { background: var(--accent2); box-shadow: 0 0 8px var(--accent2); }
.step.done { background: var(--accent2); }
.step-label { font-size: 9px; color: var(--muted); margin-top: 4px; text-align: center; }

/* 5. Bouton Save Flottant (plus clair) */
.btn-save-row {
    width: 36px; height: 36px; border-radius: 50%; 
    border: none; background: var(--accent); color: white;
    display: flex; align-items: center; justify-content: center;
    box-shadow: 0 4px 10px rgba(0,0,0,0.3);
    cursor: pointer; transition: 0.2s;
}
.btn-save-row:hover { transform: scale(1.1); background: #6b4ce6; }


/* --- AJOUTS V2 --- */

/* Style des badges d'altération (Missense, etc.) */
.alteration-badge {
    display: inline-block;
    font-size: 10px;
    font-weight: 700;
    text-transform: uppercase;
    padding: 2px 6px;
    border-radius: 4px;
    letter-spacing: 0.05em;
}
.alt-missense { background: rgba(255, 190, 80, 0.2); color: #ffbe50; border: 1px solid rgba(255, 190, 80, 0.4); }
.alt-frameshift, .alt-stop { background: rgba(255, 95, 109, 0.2); color: #ff9a9e; border: 1px solid rgba(255, 95, 109, 0.4); }
.alt-other { background: rgba(140, 160, 255, 0.1); color: #8ca0ff; border: 1px solid rgba(140, 160, 255, 0.3); }

/* Petites infos sous le gène */
.tiny-pos { font-family: 'Consolas', monospace; font-size: 10px; color: var(--muted); margin-top: 2px; }

/* Ajustement Stepper */
.stepper { display: flex; gap: 4px; height: 4px; margin-top: 4px; border-radius: 2px; overflow: hidden; background: rgba(255,255,255,0.1); }
.step { flex: 1; background: transparent; }
.step.done { background: #3ac572; } /* Vert si fait */
.step.active { background: #ffbe50; } /* Jaune si en cours */

/* --- AMÉLIORATIONS VISUELLES V3 --- */

/* 1. Nouveau statut "Gris" (À interpréter) */
tr.row-todo td {
    background: rgba(255, 255, 255, 0.03) !important;
    border-bottom: 1px solid rgba(255, 255, 255, 0.1) !important;
}
tr.row-todo td:first-child { border-left: 4px solid #6b7280; } /* Gris neutre */

/* Ajustements existants pour cohérence */
tr.row-tovalidate td:first-child { border-left: 4px solid #ffbe50; }
tr.row-validated td:first-child { border-left: 4px solid #3ac572; }
tr.row-invalidated td:first-child { border-left: 4px solid #ff5f6d; }


/* 2. Liste des lecteurs (Double lecture) */
.reviewer-list { display: flex; flex-direction: column; gap: 4px; margin-top: 6px; }
.reviewer-item {
    font-size: 10px;
    padding: 2px 6px;
    border-radius: 4px;
    background: rgba(0,0,0,0.3);
    display: flex; justify-content: space-between;
    border-left: 2px solid transparent;
}
.reviewer-item.rev-validated { border-left-color: #3ac572; color: #a3e6be; }
.reviewer-item.rev-invalidated { border-left-color: #ff5f6d; color: #ffb3ba; }

/* Zone "Ma lecture" */
.my-review-box {
    margin-bottom: 8px;
    padding: 8px;
    background: rgba(140, 160, 255, 0.05);
    border: 1px dashed rgba(140, 160, 255, 0.2);
    border-radius: 6px;
}
.btn-choice {
    flex: 1; font-size: 10px; padding: 4px;
    border: 1px solid; background: transparent; cursor: pointer;
    border-radius: 4px; transition: 0.2s;
}
.btn-choice:hover { opacity: 0.8; transform: translateY(-1px); }

/* Réduire la colonne Actionnabilité */
textarea.action-input {
    min-height: 40px !important; /* Plus petit par défaut */
    font-size: 10px !important;
}

.review-title { font-size: 10px; text-transform: uppercase; color: var(--muted); margin-bottom: 4px; }
.review-form textarea { min-height: 38px; }
.review-badge { border-radius: 999px; padding: 1px 6px; font-size: 10px; font-weight: 700; }
.review-badge-valid { background: rgba(58,197,114,0.2); color: #3ac572; border: 1px solid rgba(58,197,114,0.35); }
.review-badge-invalid { background: rgba(255,95,109,0.15); color: #ff9a9e; border: 1px solid rgba(255,95,109,0.35); }
.review-badge-pending { background: rgba(140,160,255,0.12); color: #8ca0ff; border: 1px solid rgba(140,160,255,0.35); }
.step-label-left { text-align: left; font-size: 10px; }

@media (max-width: 1600px) {
  .ngs-table th, .ngs-table td { font-size: 11px; padding: 5px 4px; }
  .ngs-table .dense-input { font-size: 11px !important; padding: 5px !important; }
  .ngs-table .action-input { min-height: 44px !important; }
}


/* Séparation visuelle subtile entre variants + alternance légère */
.variant-row td { border-bottom: 1px solid rgba(140,160,255,.16); }
.variant-row.row-alt-odd td { background: rgba(255,255,255,0.012); }
.variant-row.row-alt-even td { background: rgba(0,212,255,0.018); }

/* --- Variant knowledge UI tokens (scalable) --- */
.row-wrap{ flex-wrap: wrap; }
.u-nowrap{ white-space: nowrap; }
.u-mt-8{ margin-top: 8px; }
.u-mt-10{ margin-top: 10px; }
.u-mt-12{ margin-top: 12px; }
.u-mt-14{ margin-top: 14px; }

.context-list{ display:flex; flex-direction:column; gap:8px; }
.context-list-wide{ min-width: 520px; }
.context-row{ display:flex; align-items:center; gap:8px; flex-wrap:wrap; }

.pill-cancer{
  background: rgba(0, 212, 255, 0.12);
  border-color: rgba(0, 212, 255, 0.35);
  color: #8ee8ff;
}
.pill-source{
  background: rgba(124, 92, 255, 0.16);
  border-color: rgba(124, 92, 255, 0.38);
  color: #c9bcff;
}

.status-badge{
  font-weight: 700;
  padding: 2px 8px;
  border-radius: 999px;
  font-size: 11px;
  display: inline-flex;
  align-items: center;
  border: 1px solid transparent;
}
.status-actionable{
  background: rgba(58, 197, 114, 0.18);
  color: #8ce4ad;
  border-color: rgba(58, 197, 114, 0.44);
}
.status-neutral{
  background: rgba(140,160,255,.1);
  color: #a9b7ff;
  border-color: rgba(140,160,255,.35);
}

.gene-card-compact{ display:flex; flex-direction:column; gap:4px; }
.comment-card{ border:1px solid rgba(140,160,255,.18); border-radius:12px; padding:10px; }

.synoptic-hero{
  border-color: rgba(0,212,255,.32);
}
.synoptic-grid{
  display:grid;
  gap:10px;
  grid-template-columns: repeat(4, minmax(0, 1fr));
}
.synoptic-block{
  border:1px solid rgba(140,160,255,.25);
  border-radius:12px;
  padding:10px;
  background: rgba(8,14,30,.55);
  transition: border-color .15s ease, transform .15s ease;
}
.synoptic-block:hover{ border-color: rgba(0,212,255,.45); transform: translateY(-1px); }
.synoptic-label{ font-size:11px; color:var(--muted); text-transform:uppercase; letter-spacing:.04em; }
.synoptic-value{ font-size:16px; font-weight:700; margin-top:4px; }
.interactive-row{ transition: background-color .16s ease, transform .16s ease; }
.interactive-row:hover{ background-color: rgba(124,92,255,.08); transform: translateX(1px); }

.quick-nav{
  display:flex;
  gap:8px;
  flex-wrap:wrap;
  position: sticky;
  top: 8px;
  z-index: 8;
  margin: 0 0 12px 0;
  padding: 8px;
  border: 1px solid rgba(140,160,255,.18);
  border-radius: 12px;
  background: linear-gradient(120deg, rgba(14,22,44,.86), rgba(10,18,35,.78));
  box-shadow: 0 10px 28px rgba(0,0,0,.28);
  backdrop-filter: blur(6px);
}

.quick-nav .btn{ font-size: 10px; padding: 3px 9px; }

.pop-card-enter{
  animation: popCardEnter .34s cubic-bezier(.2,.9,.26,1) both;
}

.pop-card-enter:nth-child(2){ animation-delay: .05s; }
.pop-card-enter:nth-child(3){ animation-delay: .1s; }
.pop-card-enter:nth-child(4){ animation-delay: .15s; }

@keyframes popCardEnter{
  from { opacity: 0; transform: translateY(10px) scale(.985); }
  to { opacity: 1; transform: translateY(0) scale(1); }
}

.context-row-grid{
  display:grid;
  grid-template-columns: minmax(120px, 1.1fr) minmax(90px, auto) minmax(138px, auto) minmax(64px, auto) 1fr auto;
  gap:8px;
  align-items:center;
  border:1px solid rgba(140,160,255,.16);
  border-radius:12px;
  padding:8px 10px;
  background: rgba(7,12,26,.48);
}

.context-actions-wrap{
  display:flex;
  align-items:center;
  gap:6px;
  flex-wrap:wrap;
  justify-content:flex-start;
}

.synoptic-value-row{
  display:flex;
  align-items:center;
  gap:8px;
  flex-wrap:wrap;
  margin-top:4px;
}

/* Vue transversale en tableau (alignement fort) */
.transverse-table {
  width: 100%;
  border-collapse: separate;
  border-spacing: 0;
  border: 1px solid rgba(140,160,255,.18);
  border-radius: 12px;
  overflow: hidden;
  min-width: 980px;
}
.transverse-table th,
.transverse-table td{
  padding: 9px 10px;
  border-bottom: 1px solid rgba(140,160,255,.12);
  vertical-align: middle;
}
.transverse-table th{
  text-transform: uppercase;
  letter-spacing: .04em;
  font-size: 11px;
  color: rgba(234,240,255,.72);
  background: rgba(255,255,255,.03);
  white-space: nowrap;
}
.transverse-table tbody tr:last-child td{ border-bottom: 0; }
.transverse-table tbody tr:hover{ background: rgba(124,92,255,.08); }
.context-item-count{ white-space: nowrap; }

@media (max-width: 1200px){
  .context-row-grid{ grid-template-columns: minmax(120px, 1fr) minmax(90px, auto) minmax(138px, auto) minmax(64px, auto) 1fr; }
  .context-row-grid .btn{ grid-column: 1 / -1; width: fit-content; }
}

@media (max-width: 1050px){
  .synoptic-grid{ grid-template-columns: repeat(2, minmax(0, 1fr)); }
}
@media (max-width: 620px){
  .synoptic-grid{ grid-template-columns: 1fr; }
  .context-row-grid{ grid-template-columns: 1fr; }
}

@media (prefers-reduced-motion: reduce){
  .card,
  .btn,
  .synoptic-block,
  .interactive-row{
    animation: none !important;
    transition: none !important;
    transform: none !important;
  }
  .quick-nav{
    position: static;
  }
}

/* Home page only animated high-tech background */
.home-page::before,
.home-page::after{
  content:"";
  position: fixed;
  inset: -25vmax;
  pointer-events: none;
  z-index: -1;
}
.home-page::before{
  background:
    conic-gradient(from 0deg at 30% 40%, rgba(124,92,255,.18), rgba(0,212,255,.12), rgba(255,79,216,.12), rgba(124,92,255,.18));
  filter: blur(38px) saturate(120%);
  animation: homeAuraRotate 18s linear infinite;
}
.home-page::after{
  background:
    radial-gradient(circle at 25% 25%, rgba(0,212,255,.20), transparent 40%),
    radial-gradient(circle at 70% 60%, rgba(124,92,255,.22), transparent 42%),
    radial-gradient(circle at 55% 30%, rgba(255,79,216,.12), transparent 36%);
  animation: homePulse 8s ease-in-out infinite;
}
@keyframes homeAuraRotate { to { transform: rotate(360deg); } }
@keyframes homePulse {
  0%,100%{ opacity:.7; transform: scale(1); }
  50%{ opacity:1; transform: scale(1.05); }
}

/* NGS VAF colors */
.m-value.val-over-tumor { color: #f8ef00; text-shadow: 0 0 11px rgba(248,239,0,.65); font-weight: 900; }
.m-value.val-mid { color: #14e6d4; text-shadow: 0 0 10px rgba(20,230,212,.55); font-weight: 800; }
.m-value.val-very-high { color: #39ff14; text-shadow: 0 0 12px rgba(57,255,20,.6); font-weight: 800; }
.m-value.val-low {
  color: #ff3f4f;
  text-shadow: 0 0 12px rgba(255,63,79,.7);
  font-weight: 900;
  animation: vafLowPulse 1s ease-in-out infinite;
}
.m-value .vaf-alert-icon{
  display:inline-block;
  margin-left:6px;
  filter: drop-shadow(0 0 10px rgba(255,220,75,.75));
  animation: vafWarnBlink .9s ease-in-out infinite;
}
.m-value.val-multi{
  position: relative;
  padding: 0 5px;
  border-radius: 6px;
  border: 1px solid rgba(255,255,255,.75);
  box-shadow: 0 0 0 1px rgba(255,255,255,.35), inset 0 0 0 1px rgba(255,255,255,.25);
}
.m-value .vaf-multi-icon{
  display:inline-block;
  margin-left:4px;
  color:#ffffff;
  font-size:10px;
  opacity:.95;
}
@keyframes vafLowPulse {
  0%, 100% { color:#ff3f4f; text-shadow: 0 0 9px rgba(255,63,79,.65); }
  50% { color:#ffeb3b; text-shadow: 0 0 15px rgba(255,235,59,.95); }
}
@keyframes vafWarnBlink {
  0%,100% { transform: scale(1); opacity: .55; }
  50% { transform: scale(1.15); opacity: 1; }
}

/* Checklist status slider */
.status-slider-wrap{ margin-bottom:8px; }
.status-slider-row{ display:flex; align-items:center; gap:12px; }
.status-slider{ flex:1; min-width:220px; accent-color:#7C5CFF; }
.status-slider-labels{ display:grid; grid-template-columns:repeat(4,1fr); gap:6px; margin-top:4px; font-size:11px; color:var(--muted); }
.status-chip{ display:inline-flex; align-items:center; gap:6px; padding:4px 10px; border-radius:999px; border:1px solid rgba(140,160,255,.26); font-size:11px; }
.status-chip .dot{ width:8px; height:8px; }
.status-chip-planned{ border-color: rgba(140,160,255,.45); }
.status-chip-progress{ border-color: rgba(0,212,255,.45); }
.status-chip-done{ border-color: rgba(58,197,114,.45); }
.status-chip-na{ border-color: rgba(239,83,80,.45); }

/* --- V4: Checklist futuriste lisible --- */
.checklist-form{
  display: grid;
  gap: 10px;
}

.exam-meta-card{
  display:flex;
  flex-direction:column;
  gap:8px;
  max-width: 430px;
  padding: 12px;
  border-radius: 14px;
  border: 1px solid rgba(140,160,255,.22);
  background: linear-gradient(145deg, rgba(17,27,56,.86), rgba(8,16,34,.86));
  box-shadow: inset 0 0 0 1px rgba(255,255,255,.03), 0 14px 34px rgba(0,0,0,.28);
}

.exam-meta-top{
  display:flex;
  justify-content:space-between;
  align-items:center;
  gap:8px;
}

.exam-title{
  letter-spacing:.04em;
  font-size: 14px;
  text-transform: uppercase;
}

.exam-state-pill{
  display:inline-flex;
  align-items:center;
  justify-content:center;
  padding: 4px 10px;
  border-radius: 999px;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: .08em;
  color: #71f6ff;
  border: 1px solid rgba(50,243,255,.45);
  background: rgba(50,243,255,.14);
  box-shadow: 0 0 22px rgba(50,243,255,.20);
}

.exam-detail{
  font-size:12px;
  color: rgba(234,240,255,.9);
  line-height: 1.5;
}

.exam-help{
  display:flex;
  gap:8px;
  padding: 8px 10px;
  border-radius: 10px;
  background: linear-gradient(135deg, rgba(255,79,216,.13), rgba(0,212,255,.08));
  border: 1px solid rgba(255,79,216,.26);
  color: rgba(234,240,255,.82);
  font-size: 11px;
  line-height: 1.45;
}

.exam-help-icon{
  filter: drop-shadow(0 0 8px rgba(255,79,216,.55));
}

.status-slider-wrap{
  margin-bottom:6px;
  width: min(100%, 580px);
  border: 1px solid rgba(140,160,255,.24);
  border-radius: 14px;
  padding: 10px;
  background: linear-gradient(160deg, rgba(11,19,39,.88), rgba(9,15,31,.88));
}

.status-slider-row{ gap: 14px; }

.status-slider{
  accent-color:#00D4FF;
  filter: drop-shadow(0 0 8px rgba(0,212,255,.32));
}

.status-slider-labels{
  margin-top:8px;
  font-size: 10px;
  letter-spacing: .08em;
  text-transform: uppercase;
  color: rgba(234,240,255,.72);
}

.status-chip{
  min-width: 132px;
  justify-content: center;
  font-weight: 700;
  letter-spacing: .05em;
  text-transform: uppercase;
  padding: 6px 10px;
  background: rgba(255,255,255,.04);
}

.status-chip-planned{ border-color: rgba(140,160,255,.52); color:#c9d4ff; }
.status-chip-progress{ border-color: rgba(0,212,255,.52); color:#83f4ff; box-shadow:0 0 18px rgba(0,212,255,.18); }
.status-chip-done{ border-color: rgba(58,197,114,.52); color:#9bf2bf; box-shadow:0 0 18px rgba(58,197,114,.18); }
.status-chip-na{ border-color: rgba(239,83,80,.52); color:#ffc2c1; }

.ngs-double-read-card{
  margin-top:12px;
  width:min(100%, 700px);
  border-radius:14px;
  border:1px solid rgba(130,224,255,.28);
  background:linear-gradient(150deg, rgba(10,24,48,.92), rgba(13,33,64,.84));
  box-shadow:inset 0 0 0 1px rgba(255,255,255,.04), 0 14px 30px rgba(0,0,0,.25);
  padding:12px;
}

.ngs-double-read-head{
  display:flex;
  align-items:center;
  justify-content:space-between;
  gap:10px;
  margin-bottom:10px;
}

.ngs-double-read-head h3{
  margin:0;
  font-size:13px;
  letter-spacing:.05em;
  text-transform:uppercase;
}

.ngs-double-read-status{
  display:inline-flex;
  align-items:center;
  padding:4px 10px;
  border-radius:999px;
  font-size:10px;
  text-transform:uppercase;
  letter-spacing:.08em;
  border:1px solid rgba(80,220,255,.48);
  background:rgba(38,201,255,.14);
  color:#98f3ff;
}

.ngs-double-read-grid{
  display:grid;
  grid-template-columns:repeat(4, minmax(110px, 1fr));
  gap:8px;
}

.ngs-metric{
  padding:9px;
  border-radius:10px;
  border:1px solid rgba(140,160,255,.24);
  background:rgba(7,18,36,.6);
  display:flex;
  flex-direction:column;
  gap:6px;
}

.ngs-metric span{
  font-size:10px;
  text-transform:uppercase;
  letter-spacing:.08em;
  color:rgba(228,236,255,.75);
}

.ngs-metric b{
  font-size:20px;
  line-height:1;
  color:#f2f8ff;
}

.ngs-metric.validated b{ color:#8dffb1; }
.ngs-metric.invalidated b{ color:#ff95ad; }
.ngs-metric.one-review b{ color:#ffe59f; }

.ngs-double-read-card.tone-complete{
  border-color:rgba(84,214,140,.42);
  background:linear-gradient(150deg, rgba(8,40,34,.9), rgba(9,29,46,.85));
}
.ngs-double-read-card.tone-complete .ngs-double-read-status{
  border-color:rgba(84,214,140,.55);
  background:rgba(84,214,140,.18);
  color:#b7ffd3;
}

.ngs-double-read-card.tone-todo{
  border-color:rgba(255,177,96,.42);
  background:linear-gradient(150deg, rgba(40,24,8,.86), rgba(22,22,48,.84));
}
.ngs-double-read-card.tone-todo .ngs-double-read-status{
  border-color:rgba(255,177,96,.58);
  background:rgba(255,177,96,.2);
  color:#ffe4bb;
}


.checklist-option-grid{
  display:grid;
  gap:8px;
  width:min(100%, 680px);
}

.checklist-checkbox{
  display:flex;
  align-items:flex-start;
  gap:10px;
  padding:8px 10px;
  border-radius:10px;
  border:1px solid rgba(140,160,255,.28);
  background:rgba(10,18,38,.55);
  color:rgba(234,240,255,.92);
  font-size:12px;
  line-height:1.4;
}

.checklist-checkbox input[type="checkbox"]{
  margin-top:2px;
  width:16px;
  height:16px;
  accent-color:#22d3ee;
  filter: drop-shadow(0 0 4px rgba(34,211,238,.35));
}

.btn-checklist-save{
  border-color: rgba(255,79,216,.52);
  background: linear-gradient(120deg, rgba(255,79,216,.32), rgba(0,212,255,.25));
  color: #fff;
  font-weight: 700;
  letter-spacing: .03em;
  box-shadow: 0 10px 24px rgba(255,79,216,.18);
}

.checklist-grid-row{
  display:grid;
  grid-template-columns: minmax(220px,1.05fr) minmax(270px,1.2fr) minmax(360px,1.7fr) minmax(260px,1.2fr) minmax(190px,.75fr);
  gap:12px;
  align-items:start;
}

.checklist-col{
  display:flex;
  flex-direction:column;
  gap:10px;
  min-width:0;
}

.checklist-col-form .checklist-form input,
.checklist-col-form .checklist-form textarea,
.checklist-col-reports textarea{
  width:100%;
}

.checklist-col-actions{ justify-content:flex-start; }
.checklist-col-actions .btn{ width:100%; justify-content:center; }

.checklist-report-actions .btn{
  width:100%;
  justify-content:center;
  font-weight:700;
}

.btn-report-synoptic{
  border-color: rgba(40,243,255,.55);
  background: linear-gradient(130deg, rgba(0,212,255,.26), rgba(58,112,255,.22));
  color:#ddf9ff;
  box-shadow: 0 10px 22px rgba(0,212,255,.18);
}

.btn-report-pdf{
  border-color: rgba(255,176,70,.55);
  background: linear-gradient(130deg, rgba(255,157,0,.28), rgba(255,79,216,.2));
  color:#fff3e0;
  box-shadow: 0 10px 22px rgba(255,157,0,.2);
}

.ngs-double-read-users{
  margin-top:10px;
  padding-top:10px;
  border-top:1px solid rgba(130,224,255,.2);
}

.ngs-double-read-users-title{
  font-size:10px;
  text-transform:uppercase;
  letter-spacing:.08em;
  color:rgba(226,236,255,.78);
  margin-bottom:6px;
}

.ngs-double-read-users ul{
  list-style:none;
  margin:0;
  padding:0;
  display:grid;
  gap:6px;
}

.ngs-double-read-users li{
  display:flex;
  justify-content:space-between;
  gap:8px;
  border:1px solid rgba(140,160,255,.2);
  border-radius:8px;
  padding:6px 8px;
  font-size:12px;
  background:rgba(7,18,36,.44);
}

@media (max-width: 1560px){
  .checklist-grid-row{ grid-template-columns: repeat(2, minmax(260px,1fr)); }
}

@media (max-width: 920px){
  .checklist-grid-row{ grid-template-columns: 1fr; }
}

/* --- V4: Fond home pop-art futuriste --- */
.home-fx{
  position: fixed;
  inset: 0;
  pointer-events: none;
  overflow: hidden;
  z-index: -1;
}

.home-fx span{
  position: absolute;
  border-radius: 999px;
  mix-blend-mode: screen;
}

.home-fx .ring-a{
  width: 52vmax;
  height: 52vmax;
  left: -10vmax;
  top: -8vmax;
  border: 2px solid rgba(50,243,255,.24);
  box-shadow: inset 0 0 80px rgba(50,243,255,.10), 0 0 60px rgba(50,243,255,.16);
  animation: orbitalSpin 18s linear infinite;
}

.home-fx .ring-b{
  width: 44vmax;
  height: 44vmax;
  right: -6vmax;
  top: 8vmax;
  border: 2px solid rgba(255,79,216,.22);
  box-shadow: inset 0 0 70px rgba(255,79,216,.10), 0 0 50px rgba(255,79,216,.16);
  animation: orbitalSpinReverse 22s linear infinite;
}

.home-fx .beam-a,
.home-fx .beam-b{
  width: 140vmax;
  height: 16vmax;
  left: -25vmax;
  background: linear-gradient(90deg, transparent, rgba(255,225,77,.16), transparent);
  transform: rotate(-12deg);
  filter: blur(16px);
}

.home-fx .beam-a{ top: 28%; animation: beamShift 7s ease-in-out infinite; }
.home-fx .beam-b{ top: 62%; animation: beamShift 9s ease-in-out infinite reverse; }

.home-page::before{
  background:
    conic-gradient(from 120deg at 22% 36%, rgba(124,92,255,.20), rgba(0,212,255,.16), rgba(255,79,216,.15), rgba(124,92,255,.20));
  filter: blur(30px) saturate(130%);
  animation: homeAuraRotate 14s linear infinite;
}

.home-page::after{
  background:
    radial-gradient(circle at 20% 18%, rgba(255,79,216,.24), transparent 38%),
    radial-gradient(circle at 72% 22%, rgba(0,212,255,.24), transparent 40%),
    radial-gradient(circle at 46% 78%, rgba(255,225,77,.14), transparent 38%);
  animation: homePulse 6s ease-in-out infinite;
}

@keyframes orbitalSpin { to { transform: rotate(360deg) scale(1.04); } }
@keyframes orbitalSpinReverse { to { transform: rotate(-360deg) scale(.96); } }
@keyframes beamShift {
  0%,100% { opacity: .35; transform: translateY(0) rotate(-12deg); }
  50% { opacity: .9; transform: translateY(-14px) rotate(-10deg); }
}

@media (max-width: 860px){
  .exam-meta-card{ max-width: none; }
  .status-slider-wrap{ width: 100%; }
  .home-fx .beam-a,
  .home-fx .beam-b{ height: 24vmax; }
}


.status-toggle-wrap{
  margin-bottom: 6px;
  width: min(100%, 620px);
}

.status-toggle-group{
  display:grid;
  grid-template-columns: repeat(4, minmax(0,1fr));
  gap:8px;
}

.status-toggle-option{
  display:flex;
  align-items:center;
  justify-content:center;
  min-height: 38px;
  border-radius: 12px;
  border: 1px solid rgba(140,160,255,.32);
  background: rgba(255,255,255,.03);
  color: var(--muted);
  font-size: 11px;
  font-weight: 700;
  letter-spacing: .04em;
  text-transform: uppercase;
  cursor: pointer;
  transition: all .14s ease;
}

.status-toggle-option input{
  position:absolute;
  opacity:0;
  pointer-events:none;
}

.status-toggle-option.is-selected{
  color:#fff;
  box-shadow: inset 0 0 0 1px rgba(255,255,255,.12), 0 8px 18px rgba(0,0,0,.24);
  transform: translateY(-1px);
}

.status-toggle-option.status-chip-planned.is-selected{ background: rgba(140,160,255,.2); border-color: rgba(140,160,255,.62); }
.status-toggle-option.status-chip-progress.is-selected{ background: rgba(0,212,255,.2); border-color: rgba(0,212,255,.64); }
.status-toggle-option.status-chip-done.is-selected{ background: rgba(58,197,114,.2); border-color: rgba(58,197,114,.62); }
.status-toggle-option.status-chip-na.is-selected{ background: rgba(239,83,80,.18); border-color: rgba(239,83,80,.62); }

@media (max-width: 860px){
  .status-toggle-group{ grid-template-columns: repeat(2, minmax(0,1fr)); }
}

/* --- NGS facelift (high-tech blocks + clearer statuses) --- */
.ngs-block{
  border:1px solid rgba(64,214,255,.26);
  border-radius: 12px;
  padding: 10px;
  background: linear-gradient(145deg, rgba(8,16,34,.72), rgba(7,22,28,.62));
  box-shadow: inset 0 1px 0 rgba(255,255,255,.04), 0 8px 22px rgba(0,0,0,.26);
}
.ngs-block + .ngs-block{ margin-top: 10px; }
.ngs-block-title{
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: .08em;
  color: #67e6ff;
  margin-bottom: 8px;
  font-weight: 800;
}
.ngs-block-action{ border-color: rgba(0,216,255,.32); }
.ngs-block-classif{ border-color: rgba(76,154,255,.3); }
.ngs-block-review{ border-color: rgba(57,235,194,.28); }

.btn-save-inline{
  margin-top: 10px;
  width: 100%;
  border: 1px solid rgba(0,216,255,.55);
  border-radius: 10px;
  padding: 8px 10px;
  background: linear-gradient(135deg, #0078ff, #00d8ff);
  color: #fff;
  font-weight: 800;
  letter-spacing: .02em;
  cursor: pointer;
  box-shadow: 0 8px 18px rgba(0,122,255,.35);
  transition: transform .16s ease, box-shadow .16s ease;
}
.btn-save-inline:hover{ transform: translateY(-1px); box-shadow: 0 10px 24px rgba(0,122,255,.45); }

/* stronger reading-status visibility */
.variant-row td:first-child{ position: relative; }
tr.row-tovalidate td:first-child,
tr.row-validated td:first-child,
tr.row-invalidated td:first-child,
tr.row-todo td:first-child{ border-left-width: 8px !important; }
tr.row-tovalidate td:first-child{ border-left-color: #ffd447 !important; box-shadow: inset 8px 0 14px rgba(255,212,71,.22); }
tr.row-validated td:first-child{ border-left-color: #2dff95 !important; box-shadow: inset 8px 0 14px rgba(45,255,149,.2); }
tr.row-invalidated td:first-child{ border-left-color: #ff4d7a !important; box-shadow: inset 8px 0 14px rgba(255,77,122,.22); }

/* avoid confusion with reading colors */
.alt-missense{ background: rgba(255,170,0,.18) !important; color:#ffc247 !important; border:1px solid rgba(255,170,0,.4) !important; }
.alt-frameshift, .alt-stop{ background: rgba(255,87,34,.18) !important; color:#ff9f6e !important; border:1px solid rgba(255,87,34,.4) !important; }
.alt-other{ background: rgba(187,134,252,.18) !important; color:#cfafff !important; border:1px solid rgba(187,134,252,.4) !important; }

/* gene pill electric blue */
.gene-pill{
  background: linear-gradient(135deg, #0067ff, #00b7ff) !important;
  box-shadow: 0 6px 18px rgba(0,127,255,.48) !important;
}

.my-review-box{ background: rgba(10,22,46,.65); border:1px solid rgba(92,187,255,.28); }
.db-knowledge-box{ border-color: rgba(87,229,188,.35); background: rgba(5,24,23,.5); }

/* --- NGS UX polish: requested layout/colors/animations --- */
.variant-row + .variant-row td{
  padding-top: 10px;
}

.alt-missense{
  background: rgba(255, 126, 0, .2) !important;
  color: #ff7a00 !important;
  border: 1px solid rgba(255, 126, 0, .55) !important;
  box-shadow: 0 0 12px rgba(255, 126, 0, .2);
}
.alt-frameshift, .alt-stop{
  background: rgba(8, 8, 16, .72) !important;
  color: #ebf2ff !important;
  border: 1px solid rgba(50, 75, 255, .6) !important;
  box-shadow: 0 0 14px rgba(63, 91, 255, .28), inset 0 0 8px rgba(0,0,0,.55);
}
.alt-other{
  background: rgba(255, 16, 169, .16) !important;
  color: #ff4ec0 !important;
  border: 1px solid rgba(255, 78, 192, .5) !important;
  box-shadow: 0 0 12px rgba(255, 78, 192, .2);
}

.gene-pill,
.alteration-badge,
.pill{
  transition: transform .18s ease, box-shadow .22s ease, filter .22s ease;
}

.gene-pill:hover,
.alteration-badge:hover,
.pill:hover{
  transform: translateY(-1px);
  filter: brightness(1.06);
}

.gene-pill{
  animation: ngsChipPulse 4.2s ease-in-out infinite;
}

.alteration-badge{
  animation: ngsChipGlow 5s ease-in-out infinite;
}

@keyframes ngsChipPulse{
  0%, 100% { box-shadow: 0 6px 18px rgba(0,127,255,.42); }
  50% { box-shadow: 0 8px 22px rgba(0,160,255,.58); }
}

@keyframes ngsChipGlow{
  0%, 100% { box-shadow: 0 0 0 rgba(255,255,255,0); }
  50% { box-shadow: 0 0 10px rgba(140, 160, 255, .25); }
}

/* --- NGS continuous subtle animations & grouped super-block --- */
.ngs-super-block{
  border: 1px solid rgba(98, 210, 255, .35);
  border-radius: 14px;
  padding: 10px;
  background: linear-gradient(145deg, rgba(7,18,40,.82), rgba(7,22,32,.72));
  box-shadow: inset 0 1px 0 rgba(255,255,255,.05), 0 12px 28px rgba(0,0,0,.26);
}
.ngs-super-title{
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: .08em;
  color: #95f0ff;
  margin-bottom: 8px;
  font-weight: 800;
}

.suggestion-hint{ color:#7ce0ff; display:flex; align-items:center; gap:4px; }
.bulb-sparkle{
  display:inline-block;
  transform-origin: 50% 60%;
  animation: bulbFlicker .7s ease-in-out infinite;
  filter: drop-shadow(0 0 6px rgba(255, 225, 130, .45));
}

.pill{
  animation: chipFloat 6s ease-in-out infinite;
}

@keyframes bulbFlicker {
  0%, 100% { transform: scale(1) rotate(0deg); opacity: .9; }
  25% { transform: scale(1.08) rotate(-4deg); opacity: 1; }
  50% { transform: scale(.96) rotate(3deg); opacity: .78; }
  75% { transform: scale(1.06) rotate(-2deg); opacity: 1; }
}

@keyframes chipFloat {
  0%, 100% { transform: translateY(0); }
  50% { transform: translateY(-1px); }
}


/* NGS DB column + vivid chips + class-select coloring */
.db-knowledge-box{
  border-color: rgba(87,229,188,.45);
  background: linear-gradient(150deg, rgba(4,20,28,.86), rgba(9,30,30,.76));
  border-radius: 12px;
}
.db-card-title{
  font-size: 12px;
  font-weight: 800;
  letter-spacing: .06em;
  text-transform: uppercase;
  color: #87f6ff;
  margin-bottom: 8px;
}
.db-card-status{
  display: inline-block;
  margin-bottom: 8px;
  padding: 3px 9px;
  border-radius: 999px;
  font-size: 10px;
  border: 1px solid rgba(134,199,255,.38);
  background: rgba(38,95,162,.16);
  color: #cde7ff;
}
.db-card-status-success{
  border-color: rgba(58,197,114,.45);
  background: rgba(58,197,114,.14);
  color: #8df0b6;
}
.db-current-grid{
  display: grid;
  grid-template-columns: repeat(2, minmax(0,1fr));
  gap: 8px;
}
.db-current-grid > div{
  border: 1px solid rgba(118,224,255,.22);
  border-radius: 8px;
  padding: 6px 8px;
  background: rgba(7,16,34,.58);
}
.db-key{ display:block; font-size: 9px; text-transform: uppercase; color: var(--muted); }
.db-val{ display:block; font-size: 12px; font-weight: 700; color:#e8f7ff; margin-top: 2px; }
.db-context-table{
  width: 100%;
  margin-top: 6px;
  border-collapse: separate;
  border-spacing: 0 6px;
  font-size: 11px;
}
.db-context-table th{
  text-align: left;
  font-size: 9px;
  letter-spacing: .05em;
  text-transform: uppercase;
  color: #86c2d0;
  padding: 0 6px;
}
.db-context-table td{
  padding: 6px;
  background: rgba(7, 14, 31, .72);
  border-top: 1px solid rgba(86,190,224,.2);
  border-bottom: 1px solid rgba(86,190,224,.2);
}
.db-context-table td:first-child{ border-left:1px solid rgba(86,190,224,.2); border-radius: 8px 0 0 8px; }
.db-context-table td:last-child{ border-right:1px solid rgba(86,190,224,.2); border-radius: 0 8px 8px 0; }

.amp-tier-select.is-tier-ia{ background: rgba(229,57,53,.24) !important; border-color: rgba(229,57,53,.55) !important; color:#ffd4d1 !important; }
.amp-tier-select.is-tier-ib{ background: rgba(239,83,80,.23) !important; border-color: rgba(239,83,80,.52) !important; color:#ffdedd !important; }
.amp-tier-select.is-tier-iic{ background: rgba(142,68,173,.27) !important; border-color: rgba(142,68,173,.56) !important; color:#f0d5ff !important; }
.amp-tier-select.is-tier-iid{ background: rgba(165,105,189,.25) !important; border-color: rgba(165,105,189,.52) !important; color:#f2deff !important; }
.amp-tier-select.is-tier-iii{ background: rgba(31,120,180,.25) !important; border-color: rgba(31,120,180,.58) !important; color:#cceeff !important; }

.acmg-class-select.is-acmg-5{ background: #FDE8E7 !important; border-color:#F2B7B3 !important; color:#8F2E2A !important; }
.acmg-class-select.is-acmg-4{ background: #F2E9F8 !important; border-color:#D5BDE8 !important; color:#5D3D75 !important; }
.acmg-class-select.is-acmg-3{ background: #EAF4FE !important; border-color:#BDD9F7 !important; color:#1F4D77 !important; }
.acmg-class-select.is-acmg-2{ background: #E7F9F4 !important; border-color:#BCEADF !important; color:#1F6454 !important; }
.acmg-class-select.is-acmg-1{ background: #E7F7EE !important; border-color:#BCE6CE !important; color:#1D603A !important; }

.gene-pill{
  animation: ngsChipPulseFun 2.4s ease-in-out infinite;
}
.alteration-badge{
  animation: ngsChipGlowFun 2.2s ease-in-out infinite;
}
@keyframes ngsChipPulseFun{
  0%,100% { transform: translateY(0) scale(1); box-shadow: 0 8px 22px rgba(0,160,255,.42); }
  50% { transform: translateY(-2px) scale(1.03); box-shadow: 0 0 0 2px rgba(0,190,255,.24), 0 14px 28px rgba(0,190,255,.56); }
}
@keyframes ngsChipGlowFun{
  0%,100% { transform: translateY(0); filter: brightness(1); }
  35% { transform: translateY(-1px) scale(1.02); filter: brightness(1.08); }
  70% { transform: translateY(0); filter: brightness(1.14); box-shadow: 0 0 0 1px rgba(255,255,255,.2), 0 0 16px rgba(140,160,255,.35); }
}

/* --- Module launch CTA (NGS/FISH/...) --- */
.module-launch-btn{
  position: relative;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-width: 260px;
  padding: 12px 24px;
  margin-top: 6px;
  border-radius: 14px;
  font-size: 14px;
  font-weight: 800;
  letter-spacing: .03em;
  text-transform: uppercase;
  border: 1px solid rgba(50,243,255,.72);
  color: #f2fbff;
  background: linear-gradient(115deg, rgba(5,199,255,.24), rgba(124,92,255,.26), rgba(255,79,216,.24));
  box-shadow: 0 0 0 1px rgba(50,243,255,.24), 0 0 24px rgba(0,212,255,.35), 0 0 36px rgba(124,92,255,.2);
  animation: moduleNeonPulse 2.8s ease-in-out infinite;
}
.module-launch-btn::before{
  content:"";
  position:absolute;
  inset:-1px;
  border-radius: inherit;
  background: linear-gradient(120deg, rgba(50,243,255,.8), rgba(124,92,255,.65), rgba(255,79,216,.72));
  opacity:.36;
  filter: blur(7px);
  z-index:-1;
}
.module-launch-btn:hover{
  transform: translateY(-2px) scale(1.01);
  filter: brightness(1.12);
}
@keyframes moduleNeonPulse{
  0%,100%{ box-shadow: 0 0 0 1px rgba(50,243,255,.2), 0 0 22px rgba(0,212,255,.24), 0 0 34px rgba(124,92,255,.18); }
  50%{ box-shadow: 0 0 0 1px rgba(50,243,255,.48), 0 0 32px rgba(0,212,255,.45), 0 0 48px rgba(255,79,216,.32); }
}

/* --- NGS checklist readability uplift --- */
#checklist .table-wrap{ border-color: rgba(140,160,255,.24); background: rgba(6,12,24,.45); }
#checklist thead th{ background: rgba(255,255,255,.05); letter-spacing:.07em; font-size:11px; }
#checklist td{ padding: 10px 8px; }
#checklist textarea,
#checklist input,
#checklist select{ border-color: rgba(140,160,255,.3); background: rgba(10,18,36,.76); }
#checklist textarea:focus,
#checklist input:focus,
#checklist select:focus{ border-color: rgba(0,212,255,.58); box-shadow: 0 0 0 1px rgba(0,212,255,.2), 0 0 18px rgba(0,212,255,.2); }

.checklist-checkbox{
  display:flex;
  align-items:flex-start;
  gap:8px;
  padding:8px 10px;
  border-radius:10px;
  border:1px solid rgba(140,160,255,.24);
  background: rgba(12,20,40,.72);
}
.checklist-checkbox input[type='checkbox']{
  appearance:none;
  width:16px;
  height:16px;
  margin-top:2px;
  border-radius:4px;
  border:1px solid rgba(0,212,255,.55);
  background: rgba(0,0,0,.25);
  position:relative;
}
.checklist-checkbox input[type='checkbox']:checked{
  background: linear-gradient(135deg, rgba(0,212,255,.95), rgba(124,92,255,.95));
  box-shadow: 0 0 10px rgba(0,212,255,.45);
}
.checklist-checkbox input[type='checkbox']:checked::after{
  content:'✓';
  position:absolute;
  inset:0;
  display:flex;
  align-items:center;
  justify-content:center;
  color:white;
  font-size:11px;
  font-weight:900;
}

.fusion-card{ border-left:4px solid rgba(103,232,249,.65); }
.fusion-title-row{ display:flex; justify-content:space-between; align-items:center; gap:10px; }
.fusion-title-badge{ padding:8px 12px; border-radius:999px; background:linear-gradient(90deg,#22c55e,#06b6d4); color:#04111f; font-weight:900; animation:pulseFusion 1.8s infinite; }
@keyframes pulseFusion{ 0%{ box-shadow:0 0 0 0 rgba(34,197,94,.4);} 70%{box-shadow:0 0 0 10px rgba(34,197,94,0);} 100%{box-shadow:0 0 0 0 rgba(34,197,94,0);} }


.rna-reads-card{ border-left:4px solid rgba(124,92,255,.65); }
.rna-reads-grid{ display:grid; grid-template-columns:repeat(auto-fit,minmax(180px,1fr)); gap:10px; margin-top:8px; }
.rna-reads-grid > div{ border:1px solid rgba(140,160,255,.22); border-radius:10px; padding:10px 12px; background:rgba(8,18,38,.65); }
.rna-reads-grid span{ display:block; color:#aab8dd; font-size:12px; }
.rna-reads-grid b{ display:block; margin-top:2px; font-size:20px; color:#eaf2ff; }
.fusion-details-wrap th{ width:15%; white-space:nowrap; }
.fusion-details-wrap td{ width:35%; font-weight:600; }
.fusion-schema-block{ margin-top:10px; padding:10px; border:1px dashed rgba(92,187,255,.38); border-radius:10px; background:rgba(10,22,46,.58); }